Cerebrolysin : The Next Evolution of Medicine

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Cerebrolysin : The Next Evolution of Medicine

Cerebrolysin : The Next Evolution of Medicine

RRP: £99
Price: £9.9
£9.9 FREE Shipping

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Zhang C, Chopp M, Cui Y, Wang L, Zhang R, Zhang L, Lu M, Szalad A, Doppler E, Hitzl M, Zhang ZG (2010) Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res 88(15):3275–3281. https://doi.org/10.1002/jnr.22495

Schwab et al (1997) Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats – protective effects of Cerebrolysin https://www.ncbi.nlm.nih.gov/pubmed/9085071 Muresanu DF, Ciurea AV, Gorgan RM, Gheorghita E, Florian SI, Stan H, Blaga A, Ianovici N, Iencean SM, Turliuc D, Davidescu HB, Mihalache C, Brehar FM, Mihaescu AS, Mardare DC, Anghelescu A, Chiparus C, Lapadat M, Pruna V, Mohan D, Costea C, Costea D, Palade C, Bucur N, Figueroa J, Alvarez A (2015) A retrospective, multi-center cohort study evaluating the severity- related effects of cerebrolysin treatment on clinical outcomes in traumatic brain injury. CNS Neurol Disord Drug Targets 14(5):587–599. https://doi.org/10.2174/1871527314666150430162531 Alvarez XA, Cacabelos R, Sampedro C, Couceiro V, Aleixandre M, Vargas M, Linares C, Granizo E, Garcia-Fantini M, Baurecht W, Doppler E, Moessler H (2011) Combination treatment in Alzheimer’s disease: results of a randomized, controlled trial with cerebrolysin and donepezil. Curr Alzheimer Res 8(5):583–591. https://doi.org/10.2174/156720511796391863 Gromova OA, Torshin IY, Gogoleva IV, Pronin AV, Stelmashuk EV, Isaev NK, Genrikhs EE, Demidov VI, Volkov AY, Khaspekov GL, Alexandrova OP (2015) Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin. Zh Nevrol Psikhiatr Im S S Korsakova 115(3):65–72. https://doi.org/10.17116/jnevro20151153165-72 Panisset et al (2002) Cerebrolysin in Alzheimer’s disease: a randomized, double-blind, placebo-controlled trial with a neurotrophic agent https://www.ncbi.nlm.nih.gov/pubmed/12111446Asghari M, Meshkini A, Salehpoor F, Agazadeh J, Shakeri M, Shokohi G, Ebrahimi N, Bazzazi A, Pourhajshokr N (2014) Investigation of the effect of cerebrolysin on patients with head trauma and diffuse axonal injury. Int J Curr Res Acad Rev 2:62–69 Active substance: cerebrolysin concentrate (complex of peptides obtained from the porcine brain) 215,2mg per 1 ml Zhang L-J, Pan X-H, Wang Y-H, Sheng H-T (2003) Cerebrolysis improves the intelligence of vascular dementia patients in clinic. Chin J Clin Rehab 7:3850–3851 Chen S-D, Yang J-L, Hwang W-C, Yang D-I (2018) Emerging roles of sonic hedgehog in adult neurological diseases: neurogenesis and beyond. Int J Mol Sci 19(8). https://doi.org/10.3390/ijms19082423 Plosker GL, Gauthier S (2009) Cerebrolysin. Drugs Aging 26(11):893–915. https://doi.org/10.2165/11203320-000000000-00000

Similar pain-reducing effects have been seen in rat models of neuropathic (nerve) pain. Administration of Cerebrolysin in this setting helps to reduce mechanical pain, but not inflammatory pain[20]. However, the study was not carried out long enough to fully rule out an effect on inflammatory pain. What makes this finding significant is that it shows a reduction in pain that likely results from the neurotrophic (nerve plasticity) properties of Cerebrolysin as well as from its neurogenic (nerve growth) properties. Cerebrolysin Summary Alvarez XA, Alvarez I, Martinez A, Romero I, Benito C, Suarez I, Mourente S, Fantini M, Figueroa J, Aleixandre M, Linares C, Muresanu D, Winter S, Moessler H (2020) Serum VEGF predicts clinical improvement induced by Cerebrolysin plus donepezil in patients with advanced Alzheimer’s disease. Int J Neuropsychopharmacol. https://doi.org/10.1093/ijnp/pyaa046 Eder et al (2001) Increased density of glutamate receptor subunit 1 due to Cerebrolysin treatment: An immunohistochemical study on aged rats https://www.ncbi.nlm.nih.gov/pubmed/12197668 Onose G, Mureşanu DF, Ciurea AV, Daia Chendreanu C, Mihaescu AS, Mardare DC, Andone I, Spânu A, Popescu C, Dumitrescu A, Popescu M, Grigorean V, Ungur B, Marinescu F, Colibbeanu I, Onose L, Haras M, Sandu A, Spircu T (2009) Neuroprotective and consequent neurorehabilitative clinical outcomes, in patients treated with the pleiotropic drug cerebrolysin. J Med Life 2(4):350–360 The side effects of Cerebrolysin are rare and of mild intensity. The most frequently reported adverse reactions with Cerebrolysin are dizziness, headache, sweating, and nausea.

Hartbauer et al (2001) Effects of Cerebrolysin on the outgrowth and protection of processes of cultured brain neurons https://www.ncbi.nlm.nih.gov/pubmed/11459078



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